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孙皓修，博士，讲师。主要研究方向为肿瘤治疗性mrna疫苗的构建和开发以及细胞稳态维持的分子机制，取得系列创新性成果。主要研究成果发表于cell death & differentiation、advanced materials、cancer letters、journal for immunotherapy of cancer、lab on a chip、bmc medicine、cell proliferation等国际高水平生命科学杂志，参与多项国家级和省级科研项目。 教育经历 2016.09 – 2023.03 哈尔滨工业大学 生物医学工程 博士（导师：李钰教授） 2012.09 – 2016.06 东北农业大学 生物技术 学士 工作经历 2023.05 - 至今 哈尔滨医科大学 医工交叉学院 讲师 代表性论文 1. haoxiu sun#, chao liu#, fang han#, xiaoyu lin, liangyu cao, chenxing liu, qiuyu ji, jinjin cui, yuanfei yao, bojun wang, yuanyu liao, huan nie*, yanqiao zhang*, yu li*. the regulation loop of marveld1 interacting with parp1 in dna damage response maintains genome stability and promotes therapy resistance of cancer cells [j]. cell death differ, 2023 apr;30(4):922-937. (sci，if: 12.067) 2. rui xue#, ye tao*#, haoxiu sun#, weiyu liu, zhenyou ge, tianyi jiang, hongyuan jiang, fang han, yu li, yukun ren*. small universal mechanical module driven by a liquid metal droplet [j]. lab chip, 2021, 21(14): 2771-2780. (sci，if:7.517) 3. zhenyou ge,wenshang guo,ye tao*, haoxiu sun, xiangyu meng, liangyu cao, shanguo zhang, weiyu liu, muhammad luqman akhtar, yu li*, yukun ren*. wireless and closed-loop smart dressing for exudate management and on-demand treatment of chronic wounds. adv mater. 2023 aug 7:e2304005. epub ahead of print. (sci，if: 29.4) 4. xiaolin lu#, ruiqi liu#, yuanyu liao#, luying cui#, haoxiu sun, dongzhi zhang, bojun wang, lin fang, xin guan, yuanfei yao*, chao liu*, yanqiao zhang*. acvrl1 drives resistance to multitarget tyrosine kinase inhibitors in colorectal cancer by promoting usp15-mediated gpx2 stabilization. bmc med. 2023 sep 25;21(1):366. (sci，if=9.3) 5. peng dou, yiqun li, haoxiu sun, wanqiu xie, xiaoqing zhang, xiaohan zhang, dandan zhang, shupei qiao, yanpeng ci, huan nie, fang han*, yu li*. c1orf109l binding dhx9 promotes dna damage depended on the r-loop accumulation and enhances camptothecin chemosensitivity [j]. cell prolif, 2020, 53(9): e12875. (sci，if: 8.755) 6. chunbin zhang#, fan han#, ming shi#, haoxiu sun, yiqun li, yanpeng ci, yuanfei yao, peng dou, muhammad luqman akhtar, huan nie, jie he, yu li*. marveld1 interacting with catalase regulates reactive oxygen species metabolism and mediates the sensitivity to chemotherapeutic drugs in epithelial tumors of the reproductive system [j]. mol carcinog, 2019, 58(8): 1410-1426. (sci，if: 5.139) 7. ran tang#, yiqun li#, fang han#, zhenzhi li, xiaoyu lin, haoxiu sun, xiaoqing zhang, qinghua jiang, huan nie*, yu li*. a ctcf-binding element and histone deacetylation cooperatively maintain chromatin loops, linking to long-range gene regulation in cancer genomes [j]. front oncol, 2021, 11: 821495. (sci，if: 5.738) 8. chao liu#, ruiqi liu#, bojun wang#, jie lian#, yang yao, haoxiu sun, chunhui zhang, lin fang, xin guan, jiaqi shi, shuling han, fei zhan, shengnan luo, yuanfei yao*, tongsen zheng*, yanqiao zhang*. blocking il-17a enhances tumor response to anti-pd-1 immunotherapy in microsatellite stable colorectal cancer [j]. j immunother cancer, 2021, 9(1) (sci，if: 12.469) 9. yang yao#, chao liu#, bojun wang#, xin guan#, lin fang#, fei zhan, haoxiu sun, hengzhen li, changjie lou, feihu yan, xiaolin lu, luying cui, yuanyu liao, shuling han, yuanfei yao*, yanqiao zhang*. hoxb9 blocks cell cycle progression to inhibit pancreatic cancer cell proliferation through the dnmt1/rbl2/c-myc axis [j]. cancer lett, 2022, 533: 215595. (sci，if: 9.756) 获奖情况 1. 哈尔滨工业大学优秀博士学位论文提名奖（2023.03） 2. 哈尔滨工业大学生命科学与技术学院优秀共产党员（2021.07） |
